Publications et Brevets

El Maï M, Bird M, Allouche A, Targen S, Şerifoğlu N, Lopes-Bastos B, Guigonis JM, Kang D, Pourcher T, Yue JX, Ferreira MG. Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nat Aging. 2023 May;3(5):567-584. doi: 10.1038/s43587-023-00401-5. Epub 2023 May 4.

Darcourt J, Chardin D, Bourg V, Gal J, Schiappa R, Blonski M, Koulibaly PM, Almairac F, Mondot L, Le Jeune F, Collombier L, Kas A, Taillandier L, Verger A. Added value of [18F]FDOPA PET to the management of high-grade glioma patients after their initial treatment: a prospective multicentre study. Eur J Nucl Med Mol Imaging. 2023 Apr 22. doi: 10.1007/s00259-023-06225-0.

Bailleux C, Chardin D, Gal J, Guigonis JM, Lindenthal S, Graslin F, Arnould L, Cagnard A, Ferrero JM, Humbert O, Pourcher T. Metabolomic Signatures of Scarff-Bloom-Richardson (SBR) Grade in Non-Metastatic Breast Cancer. Cancers (Basel). 2023 Mar 23;15(7):1941. doi: 10.3390/cancers15071941.

Lévi-Strauss T, Tortorici B, Lopez O, Viau P, Ouizeman DJ, Schall B, Adhoute X, Humbert O, Chevallier P, Gual P, Fillatre L, Anty R. Radiomics, a Promising New Discipline: Example of Hepatocellular carcinoma. Diagnostics (Basel). 2023 Mar 30;13(7):1303. doi: 10.3390/diagnostics13071303.

Lopci E, Aide N, Dimitrakopoulou-Strauss A, Dercle L, Iravani A, Seban RD, Sachpekidis C, Humbert O, Gheysens O, Glaudemans AWJM, Weber WA, Van den Abbeele AD, Wahl RL, Scott AM, Pandit-Taskar N, Hicks RJ. Perspectives on joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards for [18F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors. Cancer Imaging. 2022 Dec 20;22(1):73. doi:10.1186/s40644-022-00512-z.

Occelli C, Guigonis JM, Lindenthal S, Cagnard A, Graslin F, Brglez V, Seitz-Polski B, Dellamonica J, Levraut J, Pourcher T. Untargeted plasma metabolomic fingerprinting highlights several biomarkers for the diagnosis and prognosis of coronavirus disease 19. Front Med (Lausanne). 2022 Sep 29;9:995069. doi:10.3389/fmed.2022.995069.

Chardin D, Gille C, Pourcher T, Humbert O, Barlaud M. Learning a confidence score and the latent space of a new supervised autoencoder for diagnosis and prognosis in clinical metabolomic studies. BMC Bioinformatics. 2022 Sep 1;23(1):361. doi: 10.1186/s12859-022-04900-x.

Khatir W, Humbert O, Benzaquen J, Bontoux C, Neels J, Berland L, Rivera FAG, Allegra M, Salah M, Tanga V, Bordone O, Fayada J, Lespinet-Fabre V, Bohly D, Long-Mira E, Lassalle S, Vouret V, Brest P, Mograbi B, Maniel C, Otto J, Boutros J, Heeke S, Hofman V, Marquette CH, Hofman P, Ilié M. Identification of a circulating immunological signature predictive of response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer. Clin Transl Med. 2022 Aug;12(8):e1018. doi: 10.1002/ctm2.1018.

Comte V, Schmutz H, Chardin D, Orlhac F, Darcourt J, Humbert O. Development and validation of a radiomic model for the diagnosis of dopaminergic denervation on [18F]FDOPA PET/CT. Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3787-3796. doi: 10.1007/s00259-022-05816-7.

Humbert O, Bauckneht M, Gal J, Paquet M, Chardin D, Rener D, Schiazza A, Genova C, Schiappa R, Zullo L, Rossi G, Martin N, Hugonnet F, Darcourt J, Morbelli S, Otto J. Prognostic value of immunotherapy-induced organ inflammation assessed on 18FDG PET in patients with metastatic non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3878-3891. doi:10.1007/s00259-022-05788-8.

Lopci E, Hicks RJ, Dimitrakopoulou-Strauss A, Dercle L, Iravani A, Seban RD, Sachpekidis C, Humbert O, Gheysens O, Glaudemans AWJM, Weber W, Wahl RL, Scott AM, Pandit-Taskar N, Aide N. Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [18F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0. Eur J Nucl Med Mol Imaging. 2022 Jun;49(7):2323-2341. doi:10.1007/s00259-022-05780-2.

Verger A, Kas A, Darcourt J, Guedj E. PET Imaging in Neuro-Oncology: An Update and Overview of a Rapidly Growing Area. Cancers (Basel). 2022 Feb22;14(5):1103. doi: 10.3390/cancers14051103.

Chardin D, Humbert O, Bailleux C, Burel-Vandenbos F, Rigau V, Pourcher T, Barlaud M. Primal-dual for classification with rejection (PD-CR): a novel method for classification and feature selection-an application in metabolomics studies. BMC Bioinformatics. 2021 Dec 15;22(1):594. doi: 10.1186/s12859-021-04478-w.

Pognonec P, Gustovic A, Djabari Z, Pourcher T, Barlaud M. Mitotic Index Determination on Live Cells From Label-Free Acquired Quantitative Phase Images Using a Supervised Autoencoder. IEEE/ACM Trans Comput Biol Bioinform. 2021 Nov-Dec;18(6):2828-2834. doi: 10.1109/TCBB.2021.3115876.

Tarnowska M, Chevalier Y, Briançon S, Bordes C, de Azevedo JR, Arquier D, Pourcher T, Bolzinger MA. Skin absorption of mixed halide anions from concentrated aqueous solutions. Eur J Pharm Sci. 2021 Nov 1;166:105985. doi:10.1016/j.ejps.2021.105985.

Martín M, Salleron L, Peyret V, Geysels RC, Darrouzet E, Lindenthal S, Bernal Barquero CE, Masini-Repiso AM, Pourcher T, Nicola JP. The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane. FASEB J. 2021 Aug;35(8):e21681. doi:10.1096/fj.202100303R.

Suissa L, Guigonis JM, Graslin F, Robinet-Borgomano E, Chau Y, Sedat J, Lindenthal S, Pourcher T. Combined Omic Analyzes of Cerebral Thrombi: A New Molecular Approach to Identify Cardioembolic Stroke Origin. Stroke. 2021 Aug;52(9):2892-2901. doi: 10.1161/STROKEAHA.120.032129.

Aknoun S, Yonnet M, Djabari Z, Graslin F, Taylor M, Pourcher T, Wattellier B, Pognonec P. Quantitative phase microscopy for non-invasive live cell population monitoring. Sci Rep. 2021 Feb 24;11(1):4409. doi:10.1038/s41598-021-83537-x.

Suissa L, Kotchetkov P, Guigonis JM, Doche E, Osman O, Pourcher T, Lindenthal S. Ingested Ketone Ester Leads to a Rapid Rise of Acetyl-CoA and Competes with Glucose Metabolism in the Brain of Non-Fasted Mice. Int J Mol Sci. 2021 Jan 7;22(2):524. doi: 10.3390/ijms22020524.

Suissa L, Guigonis JM, Graslin F, Doche E, Osman O, Chau Y, Sedat J, Lindenthal S, Pourcher T. Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome. Metabolites. 2020 Nov 25;10(12):483. doi: 10.3390/metabo10120483.

Castillo-Rivera F, Ondo-Méndez A, Guglielmi J, Guigonis JM, Jing L, Lindenthal S, Gonzalez A, López D, Cambien B, Pourcher T. Tumor microenvironment affects exogenous sodium/iodide symporter expression. Transl Oncol. 2021 Jan;14(1):100937. doi: 10.1016/j.tranon.2020.100937.

Cambien B, Lebrigand K, Baeri A, Nottet N, Compin C, Lamit A, Ferraris O, Peyrefitte CN, Magnone V, Henriques J, Zaragosi LE, Giorgetti-Peraldi S, Bost F, Gautier-Isola M, Rezzonico R, Barbry P, Barthel R, Mari B, Vassaux G. Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics. PLoS Pathog. 2020 Oct 19;16(10):e1008660. doi: 10.1371/journal.ppat.1008660.

Humbert O, Chardin D. Dissociated Response in Metastatic Cancer: An Atypical Pattern Brought Into the Spotlight With Immunotherapy. Front Oncol. 2020 Sep 18;10:566297. doi:10.3389/fonc.2020.566297.

Le Goas M, Testard F, Taché O, Debou N, Cambien B, Carrot G, Renault JP. How Do Surface Properties of Nanoparticles Influence Their Diffusion in the Extracellular Matrix? A Model Study in Matrigel Using Polymer-Grafted Nanoparticles. Langmuir. 2020 Sep 8;36(35):10460-10470. doi:10.1021/acs.langmuir.0c01624.

Chardin D, Paquet M, Schiappa R, Darcourt J, Bailleux C, Poudenx M, Sciazza A, Ilie M, Benzaquen J, Martin N, Otto J, Humbert O. Baseline metabolic tumor volume as a strong predictive and prognostic biomarker in patients with non-small cell lung cancer treated with PD1 inhibitors: a prospective study. J Immunother Cancer. 2020 Jul;8(2):e000645. doi: 10.1136/jitc-2020-000645.

Gal J, Bailleux C, Chardin D, Pourcher T, Gilhodes J, Jing L, Guigonis JM, Ferrero JM, Milano G, Mograbi B, Brest P, Chateau Y, Humbert O, Chamorey E. Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer. Comput Struct Biotechnol J. 2020 Jun 3;18:1509-1524. doi: 10.1016/j.csbj.2020.05.021.

Hoog C, Koulibaly PM, Dejean C, Desdoits T, Humbert O, Barranger E, Darcourt J. Comparison of 3 γ-probes for simultaneous iodine-125-seed and technetium-99m breast cancer surgery: NEMA standard characterisation with extended processing. EJNMMI Phys. 2020 Jun 5;7(1):37. doi: 10.1186/s40658-020-00299-7.

Duval X, Le Moing V, Tubiana S, Esposito-Farèse M, Ilic-Habensus E, Leclercq F, Bourdon A, Goehringer F, Selton-Suty C, Chevalier E, Boutoille D, Piriou N, Le Tourneau T, Chirouze C, Seronde MF, Morel O, Piroth L, Eicher JC, Humbert O, Revest M, Thébault E, Devillers A, Delahaye F, Boibieux A, Grégoire B, Hoen B, Laouenan C, Iung B, Rouzet F; AEPEI-TEPvENDO study group. Impact of Systematic Whole-body 18F-Fluorodeoxyglucose PET/CT on the Management of Patients Suspected of Infective Endocarditis: The Prospective Multicenter TEPvENDO Study. Clin Infect Dis. 2021 Aug 2;73(3):393-403. doi: 10.1093/cid/ciaa666.

Vincent L, Jankowski C, Arnould L, Coudert B, Rouzier R, Reyal F, Humbert O, Coutant C. Comparaison des performances prédictives du TEP-TDM et du nomogramme CGFL/Curie pour prédire la réponse histologique complète après chimiothérapie néo-adjuvante des cancers du sein HER2-positifs [Comparing prediction performances of ¹⁸F-FDG PET and CGFL/Curie nomogram to predict pathologic complete response after neoadjuvant chemotherapy for HER2-positive breast cancers]. Gynecol Obstet Fertil Senol. 2020 Sep;48(9):679-686. French. doi:10.1016/j.gofs.2020.03.015.

Hichri M, Vassaux G, Guigonis JM, Juhel T, Graslin F, Guglielmi J, Pourcher T, Cambien B. Proteomic Analysis of Iodinated Contrast Agent-Induced Perturbation of Thyroid Iodide Uptake. J Clin Med. 2020 Jan 23;9(2):329. doi:10.3390/jcm9020329.

Humbert O, Cadour N, Paquet M, Schiappa R, Poudenx M, Chardin D, Borchiellini D, Benisvy D, Ouvrier MJ, Zwarthoed C, Schiazza A, Ilie M, Ghalloussi H, Koulibaly PM, Darcourt J, Otto J. ¹⁸FDG PET/CT in the early assessment of non-small cell lung cancer response to immunotherapy: frequency and clinical significance of atypical evolutive patterns. Eur J Nucl Med Mol Imaging. 2020 May;47(5):1158-1167. doi: 10.1007/s00259-019-04573-4.

Le Goas M, Paquet M, Paquirissamy A, Guglielmi J, Compin C, Thariat J, Vassaux G, Geertsen V, Humbert O, Renault JP, Carrot G, Pourcher T, Cambien B. Improving ¹³¹I Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nanoparticles. Int J Nanomedicine. 2019 Sep 30;14:7933-7946. doi:10.2147/IJN.S211496.

Jing L, Guigonis JM, Borchiellini D, Durand M, Pourcher T, Ambrosetti D. LC-MS based metabolomic profiling for renal cell carcinoma histologic subtypes. Sci Rep. 2019 Oct 30;9(1):15635. doi: 10.1038/s41598-019-52059-y.

Martis N, Levraut M, Humbert O, Lidove O. Comment on: Muscle fluorodeoxyglucose uptake assessed by positron emission tomography-computed tomography as a biomarker of inflammatory myopathies disease activity. Rheumatology (Oxford). 2019 Dec 1;58(12):2344-2345. doi:10.1093/rheumatology/kez425

Tarnowska M, Briançon S, de Azevedo JR, Chevalier Y, Barratier C, Pourcher T, Bolzinger MA. Formulation of survival acceptor medium able to maintain the viability of skin explants over in vitro dermal experiments. Int J Cosmet Sci. 2019 Dec;41(6):617-623. doi: 10.1111/ics.12581.

Suissa L, Flachon V, Guigonis JM, Olivieri CV, Burel-Vandenbos F, Guglielmi J, Ambrosetti D, Gérard M, Franken P, Darcourt J, Pellerin L, Pourcher T, Lindenthal S. Urinary ketone body loss leads to degeneration of brain white matter in elderly SLC5A8-deficient mice. J Cereb Blood Flow Metab. 2020 Aug;40(8):1709-1723. doi: 10.1177/0271678X19873662.

Heeke S, Benzaquen J, Long-Mira E, Audelan B, Lespinet V, Bordone O, Lalvée S, Zahaf K, Poudenx M, Humbert O, Montaudié H, Dugourd PM, Chassang M, Passeron T, Delingette H, Marquette CH, Hofman V, Stenzinger A, Ilié M, Hofman P. In-house Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-small Cell Lung Cancer and Melanoma Patients. Cancers (Basel). 2019 Aug 29;11(9):1271. doi: 10.3390/cancers11091271.

Hafsi M, Preveral S, Hoog C, Hérault J, Perrier GA, Lefèvre CT, Michel H, Pignol D, Doyen J, Pourcher T, Humbert O, Thariat J, Cambien B. RGD-functionalized magnetosomes are efficient tumor radioenhancers for X-rays and protons. Nanomedicine. 2020 Jan;23:102084. doi:10.1016/j.nano.2019.102084.

Decazes P, Hapdey S, Humbert O, Marie-Cardine A, Vera P. Uptake of Pineal Gland Visible on 18F-DOPA PET/CT With Last Generation of SiPM PET/CT. Clin Nucl Med. 2020 Jan;45(1):e67-e68. doi: 10.1097/RLU.0000000000002742.

Borra A, Morbelli S, Zwarthoed C, Bianchi A, Bergesio F, Chauvie S, Zaucha JM, Taszner M, Malkowski B, Biggi A, Thyss A, Darcourt J, Gallamini A. Dual-point FDG-PET/CT for treatment response assessment in Hodgkin lymphoma, when an FDG-avid lesion persists after treatment. Am J Nucl Med Mol Imaging. 2019 Jun 15;9(3):176-184.

Humbert O, Bourg V, Mondot L, Gal J, Bondiau PY, Fontaine D, Barriere J, Saada-Bouzid E, Paquet M, Chardin D, Almairac F, Vandenbos F, Darcourt J. Correction to: ¹⁸F-DOPA PET/CT in brain tumors: impact on multidisciplinary brain tumor board decisions. Eur J Nucl Med Mol Imaging. 2019 Jul;46(7):1581. doi: 10.1007/s00259-019-04321-8. Erratum for: Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):558-568.

Grapin M, Coutant C, Riedinger JM, Ladoire S, Brunotte F, Cochet A, Humbert O. Combination of breast imaging parameters obtained from 18F-FDG PET and CT scan can improve the prediction of breast-conserving surgery after neoadjuvant chemotherapy in luminal/HER2-negative breast cancer. Eur J Radiol. 2019 Apr;113:81-88. doi: 10.1016/j.ejrad.2019.02.005.

Le Goas M, Paquirissamy A, Gargouri D, Fadda G, Testard F, Aymes-Chodur C, Jubeli E, Pourcher T, Cambien B, Palacin S, Renault JP, Carrot G. Irradiation Effects on Polymer-Grafted Gold Nanoparticles for Cancer Therapy. ACS Appl Bio Mater. 2019 Jan 22;2(1):144-154. doi: 10.1021/acsabm.8b00484.

Humbert O, Bourg V, Mondot L, Gal J, Bondiau PY, Fontaine D, Saada-Bouzid E, Paquet M, Chardin D, Almairac F, Vandenbos F, Darcourt J. 18F-DOPA PET/CT in brain tumors: impact on multidisciplinary brain tumor board decisions. Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):558-568. doi:10.1007/s00259-018-4240-8.

Martín M, Modenutti CP, Peyret V, Geysels RC, Darrouzet E, Pourcher T, Masini-Repiso AM, Martí MA, Carrasco N, Nicola JP. A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I- Symporter. Endocrinology. 2019 Jan 1;160(1):156-168. doi: 10.1210/en.2018-00603.

Benderitter M, Pourcher T, Martin JC, Darcourt J, Guigon P, Caire-Maurisier F, Pech A, Lebsir D, Rosique C, Guglielmi J, Rebière F, Tack K, Phan G, Lestaevel P, Souidi M, Jourdain JR. DO MULTIPLE ADMINISTRATIONS OF STABLE IODINE PROTECT POPULATION CHRONICALLY EXPOSED TO RADIOACTIVE IODINE: WHAT IS PRIODAC RESEARCH PROGRAM (2014-22) TEACHING US? Radiat Prot Dosimetry. 2018 Dec 1;182(1):67-79. doi: 10.1093/rpd/ncy129

Humbert O, Lasserre M, Bertaut A, Fumoleau P, Coutant C, Brunotte F, Cochet A. Breast Cancer Blood Flow and Metabolism on Dual-Acquisition 18F-FDG PET: Correlation with Tumor Phenotype and Neoadjuvant Chemotherapy Response. J Nucl Med. 2018 Jul;59(7):1035-1041. doi:10.2967/jnumed.117.203075.

Humbert O, Riedinger JM, Chardin D, Desmoulins I, Brunotte F, Cochet A. SUV calculation in breast cancer: which normalization should be applied when using 18F-FDG PET? Q J Nucl Med Mol Imaging. 2019 Dec;63(4):399-407. doi:10.23736/S1824-4785.18.03006-6.